A hypothalamic neuropeptide that stimulates GnRH release and is being investigated for fertility and hypogonadism.
Molecular Weight
1302.4 Da
Half-Life
~28 minutes
Typical Dose
1–10 mcg/kg
Cycle Length
4–8 weeks
Description
Kisspeptin is a family of neuropeptides encoded by the KISS1 gene, produced primarily in the arcuate nucleus and anteroventral periventricular nucleus of the hypothalamus. The most studied form for research purposes is Kisspeptin-10 (KP-10), the C-terminal decapeptide. Kisspeptin is recognized as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis — without kisspeptin signaling, puberty does not occur and reproductive function is absent. It has been investigated in Phase I and II clinical trials for hypogonadotropic hypogonadism, female infertility, and as a diagnostic tool for HPG axis assessment. Kisspeptin levels are regulated by sex steroids (both positive and negative feedback), metabolic status (leptin, insulin), and stress, making it a key integrator of reproductive and metabolic signaling.
FrequencyPulsatile (every 90 minutes) or as directed
Investigated Benefits
Stimulates LH and FSH release
Potential treatment for hypogonadotropic hypogonadism
Fertility enhancement
Testosterone optimization
Preserves HPG axis function
* Benefits based on preclinical/animal research unless otherwise noted.
Peptide Protocol Education Portal
Members-Only Access
Access advanced peptide education, protocol insights, and research-based information curated for informed users. Create a free account or log in to continue.
Please acknowledge the disclaimer above to continue.