Hormone & GHStrong Evidence

HCG

Human Chorionic Gonadotropin

A naturally occurring gonadotropin that stimulates testosterone production and maintains testicular function during TRT.

Molecular Weight

~36,700 Da

Half-Life

~24 hours

Typical Dose

250–500 IU

Cycle Length

Ongoing (with TRT) or 4–6 weeks (PCT)

Description

Human Chorionic Gonadotropin (HCG) is a glycoprotein hormone naturally produced by the syncytiotrophoblast cells of the placenta during pregnancy. It is structurally similar to luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH), all sharing a common alpha subunit with unique beta subunits conferring receptor specificity. In research and wellness contexts, HCG is used to stimulate endogenous testosterone production in men, prevent testicular atrophy during exogenous androgen use, and support fertility. It is also used in post-cycle therapy (PCT) protocols to restore the hypothalamic-pituitary-gonadal (HPG) axis after suppression. In women, HCG triggers ovulation and is used in assisted reproductive technologies.

Key Characteristics

Molecular FormulaGlycoprotein

Molecular Weight~36,700 Da

Half-Life~24 hours

Administration RoutesSubcutaneous injection, Intramuscular injection

Typical Dose250–500 IU

Frequency2–3x per week

Investigated Benefits

Maintains testicular function during TRT

Preserves fertility

Stimulates endogenous testosterone

Prevents testicular atrophy

* Benefits based on preclinical/animal research unless otherwise noted.

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