A tetrapeptide derived from the pineal gland that activates telomerase and has demonstrated lifespan extension in multiple animal models.
Molecular Weight
390.35 Da
Half-Life
~2 hours
Typical Dose
5–10 mg daily
Cycle Length
10 days, 1–2x per year
Description
Epithalon (also spelled Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from Epithalamin, a natural polypeptide extract of the pineal gland. It was developed by the St. Petersburg Institute of Bioregulation and Gerontology under the direction of Professor Vladimir Khavinson, who has published extensively on its effects in aging research. Epithalon is best known for its ability to activate telomerase — the enzyme responsible for maintaining telomere length — and has been studied in the context of longevity, cancer prevention, and circadian rhythm regulation. Animal studies have shown life extension of 20–30% in rodents, and human studies (primarily from Russian research groups) have reported improvements in various biomarkers of aging. It also regulates melatonin production and has demonstrated antioxidant and immunomodulatory properties.
* Benefits based on preclinical/animal research unless otherwise noted.
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