Description

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring nonapeptide (9 amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated in 1977 from the cerebral venous blood of rabbits by Monnier and colleagues at the University of Basel. It is found endogenously in the hypothalamus, pituitary, and limbic system, as well as in peripheral tissues including the adrenal gland and gut. DSIP promotes slow-wave (delta) sleep, reduces stress-induced ACTH and cortisol release, has demonstrated analgesic properties, and exhibits antioxidant activity. Research has also explored its potential in managing withdrawal symptoms from alcohol and opioids, and in reducing pain in chronic pain syndromes. Its amphiphilic structure allows it to cross the blood-brain barrier, which is unusual for a peptide of its size.

Key Characteristics

Investigated Benefits

* Benefits based on preclinical/animal research unless otherwise noted.