AOD-9604

Anti-Obesity Drug 9604 (HGH Fragment 176-191)

A fragment of human growth hormone that targets fat metabolism without the growth-promoting effects of full HGH.

Molecular Weight

1817.1 Da

Half-Life

~30 minutes

Typical Dose

300–500 mcg

Cycle Length

8–12 weeks

Description

AOD-9604 is a modified fragment of human growth hormone (hGH) corresponding to amino acids 176–191 of the hGH sequence. Originally developed by Monash University in Australia as part of an anti-obesity drug program, it was designed to isolate the lipolytic (fat-burning) properties of HGH without triggering the growth-promoting, insulin-desensitizing, or carcinogenic risks associated with full HGH administration. The peptide completed Phase IIb clinical trials for obesity and received GRAS (Generally Recognized as Safe) status from the FDA for use as a food additive, making it one of the few research peptides with a formal safety assessment. Beyond fat loss, preclinical research has suggested potential applications in cartilage repair and osteoarthritis, adding to its research interest.

Key Characteristics

Molecular FormulaC78H123N23O23S2

Molecular Weight1817.1 Da

Half-Life~30 minutes

Administration RoutesSubcutaneous injection, Oral (limited bioavailability)

Typical Dose300–500 mcg

FrequencyOnce daily (fasted)

Investigated Benefits

Targeted fat loss (especially visceral)

No effect on blood glucose

No IGF-1 elevation

Potential cartilage repair properties

* Benefits based on preclinical/animal research unless otherwise noted.

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